The skin is the organ which mostly manifests the changes related to the ageing process and to pathological conditions of the organism. This process becomes more evident over the years due to a gradual reduction in the thickness of the epidermis and the dermis.

The thinning of the dermis is due to a gradual reduction in the activity of the fibroblasts, and consequently to an impoverishment of all the components in the extracellular matrix (collagen, elastin and hyaluronic acid) that support the epidermis and donate resistance and elasticity to it.

Thanks to Fibroskill, it is possible to preserve one's own fibroblasts interrupting the physiological ageing process the organism undergoes: this way, the young frozen cells, are able to recuperate the same cellular activity they possessed at the moment of freezing.

Fibroskill is obtained from the extraction of fibroblasts from an extremely small section of skin of about 3x3 mm from behind the ear. The sample is then put in a special kit and is sent to the Bioscience Institute laboratories.

The Fibroskill protocol foresees expansion activities aimed at multiplying the cells until they reach the ideal concentration to favour their survival and vitality.

After about two weeks, the laboratory is able to produce a 3 ml vial containing the suspension made up of vitamins, minerals and autologous fibroblasts.

The menopause is part of a biological process in which the ovaries begin to produce low levels of sexual hormones, estrogen and progesterone. The estrogens are the main female sexual hormones and promote the development of secondary sexual characters in women, they control the ovulation cycle and are involved in many aspects of the physical and emotional health of women. The progesterone mainly controls the menstrual cycle and prepares the uterus to receive the fertilized egg.

The changes involved in the menopause processes are numerous and also involve organs as the skin making it less compact and elastic. These changes are mainly related the low levels of estrogens: those, in fact, influence the production of collagen from the fibroblasts, cells located in the dermis that contribute to the formation of the connective tissue fibers.

These matrix fibers, including collagen, confer strength and elasticity to the skin and all processes of physiological aging, that involve on one hand an important reduction of the fibroblasts in the dermis and on the other hand reduced levels of estrogens, result in decreased skin elasticity and thickness. Moreover, a lack of estrogens provokes a reduction in skin hydration as well as a reduction of vascularization and in the number of fibroblasts of the dermis.


The treatment is carried out by injecting a high concentration of fibroblasts into the superficial dermis with a microscopic needle, avoiding pain or temporary imperfections.

At the end of the session, the return to every-day life is immediate and free from any discomfort. Results, visible in the following weeks, will follow the gradual increase of the collagen produced by the physiological activity of the great number of fibroblasts implanted.

The length of the treatment is related to the life cycle of the fibroblasts and therefore lasts some years.

A part of the fibroblasts expanded in the laboratory is cryopreserved to enable subsequent treatments with cells that maintain the biological age and characteristics they had at the time the original skin sample was taken.

• Using the patient's own cells (fibroblasts) prevents any risk of rejection or contagion

• The treatment may be repeated for several years thanks to the cryopreserved cells

• The use of autologous cells guarantees absolutely natural results

• The preserved fibroblasts can also be used for the treatment of skin lesions

• Freezing interrupts the aging of the preserved fibroblasts

• From a single sample of only 3x3 mm of skin it is possible to perform about 10 Fibroskill treatments

• The effectiveness of fibroblasts clinical application is widely demonstrated in literature

FIBROSKILL is obtained by 3x3 mm of skin harvested from behind the ear. The dimensions of the tissue sample are very small, this is why it is unnecessary to suture.

The sample is placed in an isothermal container which guarantees the best security, temperature and pressure conditions for the shipment of biological material.

The kit is collected by a specialised delivery service and taken to the Bioscience Institute Cell Factory in a very short time, respecting the necessary procedures required by the.

The Biologists at Bioscience Institute will process the sample to isolate and expand a homogeneous population of fibroblasts respecting the maximum biological security conditions.

After the expansion, the cells undergo programmed freezing in order to interrupt any process of senescence and to guarantee an optimal cellular viability in the future.

Cryopreserved fibroblasts will be available for defreezing and expansion at any time after 10 days notice in advance, and it will be possible to carry out about ten FIBROSKILL treatments with a high concentration of autologous fibroblasts.

Date Headline Title Author Link
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