The natural skin aging process is characterized by dermal atrophy, variations in the content and the thickness of the layer of collagen, reduction of dermal vascularization, loss of subcutaneous fat, loss of elasticity and increased glycation.
Youthful skin uses, for regeneration and repair of the damages, cytokines, growth factors and matrix molecules; numerous studies, in fact, have shown that these molecules, secreted from human cells, can synergistically slow down the aging process thanks to their anti-aging effect. Thus, for years, scientists and researchers have been attempting to synthesize alternatives to human growth factor. Today Bioscience Clinic is able to offer you the power of these signaling molecules, produced by autologous cells, in its ONLYOURS cream suite.

WHAT IS ONLYOURS
Adipose Derived Cells (ADC) are characterized by the ability to self-renew and differentiate into a diverse range of specialized cell types. Serving as body’s repair system, today they are investigated globally to treat a multitude of illnesses and diseases, repair damaged tissues and organs, regenerate wounds and to rejuvenate aged skin. Over 100 different cytokines, growth factors and matrix proteins are known to be found within media conditioned by adipose derived cells: Epidermal Growth Factor (EGF), basic Fibroblast Growth Factor (bFGF), Transforming Growth Factor ß1 (TGFß1), Vascular Endothelial Growth Factor (VEGF), Hepatocyte Growth Factor (HGF), Insulin-like Growth Factor (IGF), Platelet Derived Growth Factor (PDGF), Keratinocyte Growth Factor (KGF), Type I Collagen Fibronectin Interleukins.
When cultured in our proprietary media, ADC are able to secrete all these various cytokines, growth factors and matrix proteins, which provide numerous anti-aging benefits to promote facial rejuvenation when applied topically.
ONLYOURS is a cream suite that takes advantages of these molecules, collecting them from the medium, where cells are cultivated after extraction from adipose tissue. Thus, each person can use his/her own cytokines and growth factors.

A PERSONALIZED BEAUTY TREATMENT
The procedure to obtain our unique ONLYOURS line products starts exclusively from expanded autologous cells from adipose tissue, with an exclusive protocol implemented by Bioscience Clinic. The result is a cream specially tailored for each patients’ skin type, since it is supplemented with a personal and unique mix of growth factors, cytokines and matrix proteins, which help boost collagen and elastin. This is possible since these molecules are collected from the medium (called conditioned medium) in which patient’s ADC are cultured, resulting in an exclusive product specific for each person, which guarantee the most personalized cream suite possible.
This unique therapy, derived from the topical use of these creams, helps in strengthening the skin’s extracellular matrix effectively for repairing the visible signs of aging, including fine lines and wrinkles, reducing the appearance of hyperpigmentation and protection from harmful oxidative environmental stress.

THE PROCEDURE STEP BY STEP
Through a unique combination of cellular research, and our ability to extract and process the body’s cells from adipose tissue via a mini-lipo procedure, Bioscience Clinic team is able to harness the power of the signaling molecules produced by autologous cells.
Our procedure begins with a small fat collection (about 10 ml). The adipose tissue is then delivered to our laboratory where the isolation of the ADC takes place. Cells extracted are then cultured in our proprietary medium, that allows the production and secretion of cytokines, growth factors and extra-cellular matrix molecules.

Date Headline Title Author Link
2015 May Stem Cells Dev. Antiphotoaging effect of conditioned medium of dedifferentiated adipocytes on skin in vivo and in vitro: a mechanistic study Xu Y1, Zhang JA, Xu Y, Guo SL, Wang S, Wu D, Wang Y, Luo D, Zhou BR.
2009 Jun Arch Dermatol Res. Protective role of adipose-derived stem cells and their soluble factors in photoaging. Kim WS1, Park BS, Sung JH.
2008 Jun J Cosmet Laser Ther. Clinical, histologic, and ultrastructural changes after use of human growth factor and cytokine skin cream for the treatment of skin rejuvenation Hussain M, Phelps R, Goldberg DJ.
2007 Oct J Drugs Dermatol. Human growth factor and cytokine skin cream for facial skin rejuvenation as assessed by 3D in vivo optical skin imaging. Gold MH, Goldman MP, Biron J
2007 Sep-Oct Dermatol Ther. Endogenous growth factors as cosmeceuticals. Mehta RC, Fitzpatrick RE.
2007 Feb J Drugs Dermatol. Efficacy of novel skin cream containing mixture of human growth factors and cytokines for skin rejuvenation Gold MH, Goldman MP, Biron J
2006 May Dermatologic Surgery Volume 32 Improvement in the appearance of wrinkles with topical transforming growth factor β1 and L-ascorbic acid Michelle Ehrlich, Jaggi Rao, Anju Pabby and Mitchel p. Goldman