Personalized Anti Aging Skin Care

is a process to create your own personal supply of collagen-producing Adipose Derived Cells to correct fine wrinkles, folds and lips. It is a fully-biological (natural) method that does not rely on injecting artificial components into the skin

THE AGING PROCESS
Fibroblasts are skin cells that produce collagen and elastin. Their function is essential for maintaining elasticity and firmness of your skin. As we age, our fibroblasts reduce in number and the collagen matrix that makes up most of the dermis breaks down. This creates an imbalance that causes the dermis to become less stretchable, less resilient, more lax and prone to wrinkling (Fisher GJ1, Varani J, Voorhees JJ. Looking older: fibroblast collapse and therapeutic implications Arch Dermatol May 2008).

RESULTS
The new implanted Adipose Derived Cells produce collagen and elastin and make the skin smoother and healthier (Driskell, Ryan R. Distinct fibroblast lineages determine dermal architecture in skin development and repair Nature 2013/12/12). Reducing the appearance of fine lines, wrinkles and superficial imperfections as damaged skin cells are quickly outnumbered by the proliferation of healthy cells. Reduction of skin tightness caused by the aging and exposure to harmful rays from the sun. (Bernerd, F. and Asselineau, D. (1998). UVA exposure of human skin reconstructued in vitro induces apoptosis of dermal fibroblasts: subsequent connective tissue repair and implications in photoaging. Cell Death Differ. 5, 792-802). A boost in collagen and elastin, helps to restore the skin’s smoothness and elasticity (Ivarsson, M., Mcwhirter, A., Borg, T. K. and Rubin, K. (1998). Type I collagen synthesis in cultured human fibroblasts. Matrix Biol. 16, 409-425).

HOW FAST ARE THE RESULTS?
consists of ADIPOSE DERIVED CELL that make new collagen and they require time to form that new matrix. The younger are the skin cells the quicker are the results; the average time from injection to when you see the changes is usually only a few months and you will see continued gradual improvements for 6 months to a year.

HOW LONG WILL THOSE RESULTS LAST?
Each of us has a different “body clock” and the age affects all body processes, collagen longevity included. The duration of the result is related to the lifetime of the implanted cells, which is generally a few years.

THE PROTOCOL
About TWO WEEKS after the small FAT collection (10 ml ), almost ten vials of Adipose Derived Cells are produced. Some tens millions of cells are used for an immediate treatment and the remaining cells are frozen for the future use.

HOW MANY TREATMENTS CAN I GET FROM THE ORIGINAL TISSUE SAMPLE?
Literally tens of millions of new ADC cells are created. The tissue cells are cryopreserved (cryopreservation can maintain viable cells for decades) and can be called back into the action at any time. Thanks to , it is now possible to preserve your own cells at -196° C and pause the physiological ageing process of the skin cells. All of your cells that are not immediately used are cryopreserved (frozen) and stored at the Bioscience Clinic facility.

HOW TO STOP THE AGEING PROCESS OF THE SKIN AND PREVENT IMPERFECTIONS?
Preserve your ADCells today and put a stop to skin-ageing. Thanks to the innovative cell culture processes, you can now obtain millions of new cells from cryopreserved ADC that will be used to restore the conditions of young skin and replace aged cells .

WHAT ABOUT ALTERNATIVE TREATMENTS?
The so-called Fillers or Botox used to “remove” wrinkles are not involved in improving skin quality, because it remains thin and clearly aged. In contrast to the outdated treatments, directly tackles the causes of skin-aging and your skin’s imperfections, thus enhancing your skin with long-lasting and absolutely natural-looking results.

INDICATIONS
∗ Ageing Skin
∗ Skin Tightening
∗ Neck Rejuvenation
∗ Decolletage Rejuvenation
∗ Hand Rejuvenation
∗ Fine Wrinkles
∗ Peri-Oral Lines

The skin is the organ which mostly manifests the changes related to the ageing process and to pathological conditions of the organism. This process becomes more evident over the years due to a gradual reduction in the thickness of the epidermis and the dermis.

The thinning of the dermis is due to a gradual reduction in the activity of the fibroblasts, and consequently to an impoverishment of all the components in the extracellular matrix (collagen, elastin and hyaluronic acid) that support the epidermis and donate resistance and elasticity to it.

Thanks to , it is possible to preserve one's own ADC interrupting the physiological ageing process the organism undergoes: this way, the young frozen cells, are able to recuperate the same cellular activity they possessed at the moment of freezing.

Lipooskill is obtained from the extraction of Adipose Derive Cells from an extremely small collection of the Fat ( 10ml).

The protocol foresees expansion activities aimed at multiplying the cells until they reach the ideal concentration to favor their survival and vitality.

After about two weeks, the laboratory is able to produce a 3 ml vial containing the suspension made up of vitamins, minerals and autologous Adipose Derived Cells.

The menopause is part of a biological process in which the ovaries begin to produce low levels of sexual hormones, estrogen and progesterone. The estrogens are the main female sexual hormones and promote the development of secondary sexual characters in women, they control the ovulation cycle and are involved in many aspects of the physical and emotional health of women. The progesterone mainly controls the menstrual cycle and prepares the uterus to receive the fertilized egg.

The changes involved in the menopause processes are numerous and also involve such organ as the skin, making it less compact and elastic. These changes are mainly related to the low levels of estrogens: those, in fact, influence the production of collagen from the fibroblasts, cells located in the dermis that contribute to the formation of the connective tissue fibers.

These matrix fibers, including collagen, confer strength and elasticity to the skin and all processes of physiological aging, that involve on one hand an important reduction of the fibroblasts in the dermis and on the other hand reduced levels of estrogens, result in decreased skin elasticity and thickness. Moreover, a lack of estrogens provokes a reduction in skin hydration as well as a reduction of vascularization and in the number of fibroblasts of the dermis.

Anti-Aging

The treatment is carried out by injecting a high concentration of Adipose Derived Cells into the superficial dermis with a microscopic needle, avoiding pain or temporary imperfections.

At the end of the session, the return to every-day life is immediate and free from any discomfort. Results, visible in the following weeks, will follow the gradual increase of the collagen produced by the physiological activity of the great number of ADC implanted.

The length of the treatment is related to the life cycle of the Cells and therefore lasts some years.

A part of the ADC expanded in the laboratory is cryopreserved to enable subsequent treatments with cells that maintain the biological age and characteristics they had at the time the original skin sample was taken.

• Using the patient's own cells prevents any risk of rejection or contagion

• The treatment may be repeated for several years thanks to the cryopreserved cells

• The use of autologous cells guarantees absolutely natural results

• The preserved ADC can also be used for the treatment of skin lesions

• Freezing interrupts the aging of the preserved ADC

• From a single sample of 10 ml of Fat it is possible to perform about 10 treatments

• The effectiveness of ADC clinical application is widely demonstrated in literature

SAMPLING

is obtained from Fat sample of 10 ml harvested from. The dimensions of the fat sample are very small, this is why there is no need to suture.


KIT

The sample is placed in an isothermal container which guarantees the best security, temperature and pressure conditions for the shipment of biological material.


CELL FACTORY

The kit is collected by a specialized delivery service and taken to the Bioscience Institute Cell Factory in a very short time, respecting the necessary procedures required by the material.


ISOLATION - EXPANSION

Biologists at Bioscience Institute will process the sample to isolate and expand a homogeneous population of ADC respecting the maximum biological security conditions.


FREEZING - PRESERVATION

After the expansion, the cells undergo programmed freezing in order to interrupt any process of senescence and to guarantee an optimal cellular viability in the future.


TREATMENT

Cryopreserved ADC will be available for defreezing and expansion at any time after 10 days notice in advance, and it will be possible to carry out about ten treatments with a high concentration of autologous ADC.

Date Journal Headline Authors Link
2014 Jul Am Heart J. Adipose-derived regenerative cells in patients with ischemic cardiomyopathy: The PRECISE Trial. Perin EC1, Sanz-Ruiz R2, Sánchez PL2, Lasso J3, Pérez-Cano R3, Alonso-Farto JC4, Pérez-David E2, Fernández-Santos ME5, Serruys PW6, Duckers HJ6, Kastrup J7, Chamuleau S8, Zheng Y1, Silva GV1, Willerson JT1, Fernández-Avilés F9.
2014 Apr Stem Cells Transl Med Adipose stem cells used to reconstruct 13 cases with cranio-maxillofacial hard-tissue defects. Sándor GK1, Numminen J, Wolff J, Thesleff T, Miettinen A, Tuovinen VJ, Mannerström B, Patrikoski M, Seppänen R, Miettinen S, Rautiainen M, Öhman J.
2014 Feb Cytotherapy. Phase I trial: the use of autologous cultured adipose-derived stroma/stem cells to treat patients with non-revascularizable critical limb ischemia. Bura A1, Planat-Benard V2, Bourin P3, Silvestre JS4, Gross F5, Grolleau JL6, Saint-Lebese B7, Peyrafitte JA2, Fleury S2, Gadelorge M2, Taurand M2, Dupuis-Coronas S2, Leobon B8, Casteilla L9.
2013 Nov Stem Cells. Autologous adipose tissue-derived stem cells treatment demonstrated favorable and sustainable therapeutic effect for Crohn's fistula. Lee WY1, Park KJ, Cho YB, Yoon SN, Song KH, Kim do S, Jung SH, Kim M, Yoo HW, Kim I, Ha H, Yu CS.
2013 Sep Cytotherapy. Pooled human platelet lysate versus fetal bovine serum-investigating the proliferation rate, chromosome stability and angiogenic potential of human adipose tissue-derived stem cells intended for clinical use. Trojahn Kølle SF1, Oliveri RS, Glovinski PV, Kirchhoff M, Mathiasen AB, Elberg JJ, Andersen PS, Drzewiecki KT, Fischer-Nielsen A.
2013 Sep Lancet. Enrichment of autologous fat grafts with ex-vivo expanded adipose tissue-derived stem cells for graft survival: a randomised placebo-controlled trial. Kølle SF1, Fischer-Nielsen A, Mathiasen AB, Elberg JJ, Oliveri RS, Glovinski PV, Kastrup J, Kirchhoff M, Rasmussen BS, Talman ML, Thomsen C, Dickmeiss E, Drzewiecki KT.
2013 Jul Plast Reconstr Surg. Fat grafts supplemented with adipose-derived stromal cells in the rehabilitation of patients with craniofacial microsomia. Tanikawa DY1, Aguena M, Bueno DF, Passos-Bueno MR, Alonso N.
2012 Mar Appl Biochem Biotechnol. The Impact of Long-Term In Vitro Expansion on the Senescence-Associated Markers of Human Adipose-Derived Stem Cells. Safwani WK, Makpol S, Sathapan S, Chua KH.
2011 Oct J Transl Med. Stem cell treatment for patients with autoimmune disease by systemic infusion of culture-expanded autologous adipose tissue derived mesenchymal stem cells Jeong Chan Ra, et al.
2011 Sep J Cell Mol Med. Systemic transplantation of human adipose-derived stem cells stimulates bone repair by promoting osteoblast and osteoclast function Lee K. et al.
2011 Aug Tissue Cell. Adipose-derived stromal cell transplantation for treatment of stress urinary incontinence Wu G. et al
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2011 Jun J Med Case Reports. Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells: a case series Pak J. et al
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2011 Mar Aesthetic Plast Surg. Acellular Dermal Matrix Seeded with Adipose-Derived Stem Cells as a Subcutaneous Implant Orbay H, Takami Y, Hyakusoku H, Mizuno H.
2011 Mar Expert Opin Biol Ther Hypoxia and adipose-derived stem cell-based tissue regeneration and engineering Zachar V, Duroux M, Emmersen J, Rasmussen JG, Pennisi CP, Yang S, Fink T.
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2011 Feb Cell Transplant. The effect of two and three dimensional cell culture on the chondrogenic potential of human adipose-derived mesenchymal stem cells after subcutaneous transplantation with an injectable hydrogel Merceron C. et al.
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2011 Feb Exp Dermatol Adipose-derived stem cells as a new therapeutic modality for ageing skin. Kim JH, Jung M, Kim HS, Kim YM, Choi EH.
2010 Dec Stem Cells Int Cotransplantation of adipose tissue-derived insulin-secreting mesenchymal stem cells and hematopoietic stem cells: a novel therapy for insulin-dependent diabetes mellitus Vanikar AV. et al
2010 Dec Surg Today Human adipose-derived stem cells: Potential clinical applications in surgery. Utsunomiya T, Shimada M, Imura S, Morine Y, Ikemoto T, Mori H, Hanaoka J, Iwahashi S, Saito Y, Iwaguro H.
2010 Sep Stem Cells Dev. Endothelial Differentiation of Adipose-Derived Stem Cells from Elderly Patients with Cardiovascular Disease. Zhang P, Moudgill N, Hager E, Tarola N, Dimatteo C, McIlhenny S, Tulenko TN, Dimuzio P.
2010 Sep J Plast Reconstr Aesthet Surg. Regeneration potential and survival of transplanted undifferentiated adipose tissue-derived stem cells in peripheral nerve conduits. Erba P, Mantovani C, Kalbermatten DF, Pierer G, Terenghi G, Kingham PJ.
2010 Sep J Biomed Mater Res A Application of different strain regimes in two-dimensional and three-dimensional adipose tissue-derived stem cell cultures induces osteogenesis: implications for bone tissue engineering. Diederichs S, Böhm S, Peterbauer A, Kasper C, Scheper T, van Griensven M.
2010 Aug Cytotherapy Adipose tissue-derived stem cells show both immunogenic and immunosuppressive properties after chondrogenic differentiation. Technau A, Froelich K, Hagen R, Kleinsasser N.
2010 Aug Mol Imaging Biol. Tracking Long-Term Survival of Intramyocardially Delivered Human Adipose Tissue-Derived Stem Cells Using Bioluminescence Imaging. Bai X, Yan Y, Coleman M, Wu G, Rabinovich B, Seidensticker M, Alt E.
2010 Jul Prostate Effects of transplantation of adipose tissue-derived stem cells on prostate tumor. Lin G, Yang R, Banie L, Wang G, Ning H, Li LC, Lue TF, Lin CS.
2010 Jun Curr Stem Cell Res Ther. Aesthetic cardiology: adipose-derived stem cells for myocardial repair. Palpant NJ, Metzger JM.
2010 gun Stem Cell Res Ther. Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells. Gimble JM, Guilak F, Bunnell BA.
2010 May Cell Biology International Promotion of human adipose-derived stem cell proliferation mediated by exogenous nucleosides Fernando Rodríguez-Serrano, Pablo Álvarez, Octavio Caba, Manuel Picón, Juan Antonio Marchal, Macarena Perán, José Prados, Consolación Melguizo, Ana Rosa Rama, Houria Boulaiz and Antonia Aránega
2010 May Cell Biol Int. Changes in the expression pattern of mesenchymal and pluripotent markers in human adipose-derived stem cells. Park E, Patel AN.
2010 May Biotechnol Bioeng. Extent of cell differentiation and capacity for cartilage synthesis in human adult adipose-derived stem cells: Comparison with fetal chondrocytes Mahmoudifar N, Doran PM.
2010 May Cell Transplant Adipocyte Transplantation and Stem Cells: Plastic Surgery Meets Regenerative Medicine Tremolada C, Palmieri G, Ricordi C.
2010 Apr Nature Reviews Endocrinology Transplantation of adipose tissue and stem cells: role in metabolism and disease Thien T. Tran & C. Ronald Kahn
2010 Mar Short Communication Adipose Tissue-Derived Mesenchymal Stem Cells Facilitate Hematopoiesis In Vitro and In Vivo. Advantages Over Bone Marrow-Derived Mesenchymal Stem Cells Norihiko Nakao*, Takayuki Nakayama*, Takashi Yahata{dagger}, Yukari Muguruma{dagger}, Shigeki Saito*, Yasuhiko Miyata*, Koji Yamamoto{ddagger}, and Tomoki Naoe
2010 Mar Case Report Med. Adipose-derived stem cells in Crohn's rectovaginal fistula. García-Olmo D, Herreros D, De-La-Quintana P, Guadalajara H, Trébol J, Georgiev-Hristov T, García-Arranz M.
2010 Mar Breast J. Progenitor-enriched adipose tissue transplantation as rescue for breast implant complications.             Yoshimura K, Asano Y, Aoi N, Kurita M, Oshima Y, Sato K, Inoue K, Suga H, Eto H, Kato H, Harii K.
2010 Mar J Craniofac Surg. In vivo cartilage formation using chondrogenic-differentiated human adipose-derived mesenchymal stem cells mixed with fibrin glue Jung SN, Rhie JW, Kwon H, Jun YJ, Seo JW, Yoo G, Oh DY, Ahn ST, Woo J, Oh J.
2010 Feb Mol Ther. Adipose-derived stem cells as therapeutic delivery vehicles of an oncolytic virus for glioblastoma Josiah DT, Zhu D, Dreher F, Olson J, McFadden G, Caldas H.
2010 Gen Int J Urol. Periurethral injection of autologous adipose-derived stem cells for the treatment of stress urinary incontinence in patients undergoing radical prostatectomy: report of two initial cases. Yamamoto T, Gotoh M, Hattori R, Toriyama K, Kamei Y, Iwaguro H, Matsukawa Y, Funahashi Y.
2010 Cytotherapy Treatment of stress urinary incontinence with adipose tissue-derived stem cells. Lin G, Wang G, Banie L, Ning H, Shindel AW, Fandel TM, Lue TF, Lin CS.
2009 Dic J Plast Reconstr Aesthet Surg. Tissue engineering with adipose-derived stem cells (ADSCs): current and future applications Sterodimas A, de Faria J, Nicaretta B, Pitanguy I.
2009 Nov J Craniofac Surg. In vitro osteogenic differentiation of adipose stem cells after lentiviral transduction with green fluorescent protein. Wang Q, Steigelman MB, Walker JA, Chen S, Hornsby PJ, Bohnenblust ME, Wang HT.
2009 Nov Arterioscler Thromb Vasc Biol. Adipose tissue-derived stem cells: characterization and potential for cardiovascular repair Madonna R, Geng YJ, De Caterina R.
2009 Nov ANZ J Surg. Human adipose-derived stem cells: isolation, characterization and applications in surgery. Caviggioli F, Vinci V, Salval A, Klinger M.
2009 Oct J Tissue Eng Regen Med. Culture effects of epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) on cryopreserved human adipose-derived stromal/stem cell proliferation and adipogenesis. Hebert TL, Wu X, Yu G, Goh BC, Halvorsen YD, Wang Z, Moro C, Gimble JM.
2009 Aug Lab Invest. Differential expression of stem-cell-associated markers in human hair follicle epithelial cells Inoue K, Aoi N, Sato T, Yamauchi Y, Suga H, Eto H, Kato H, Araki J, Yoshimura K.
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2009 Jan Int J Colorectal Dis. Treatment of enterocutaneous fistula in Crohn's Disease with adipose-derived stem cells: a comparison of protocols with and without cell expansion García-Olmo D. et al
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