BIOLOGICAL WRINKLE FILLER - LIPOSKILL

LIPOSKILL is wrinkle-filling product containing 100% autologous cells from the one’s own fat. It is a safe and fully-natural method that does not rely on injecting artificial components into the skin and instantly restores lost volume to the face for a natural look with a simple injection. It can be used all over the face, neck and neckline for such a treatments such as filling fine-to-deep wrinkles and deep skin breaks. It can also be used for cheek augmentation, nose reshaping, hands rejuvenation avoiding surgery, anesthesia, scalpel or stitches.

THE PROTOCOL
From only one harvest of 20ml of fat it is possible to obtain about 10 vials of cells that can be used for many fillers (the exact number of vials obtained is correlated with the characteristics of the fat tissue). The exclusive processes of Bioscience Laboratory guarantee the isolation and expansion of a homogeneous population of mesenchymal cells, following two protocols: the cryopreservation and the graft. In fact, cells may be used immediately to perform a treatment and can be frozen for future treatments. The newly activated cells go to work causing a dynamic regeneration response at the cellular level while filling the furrows caused by aging. Youthful beauty is restored by introducing millions of powerful new cells into the skin to eliminate facial lines, wrinkles, scars and replace lost skin volume.

WHY THE FAT?
It is known that fat tissue is amazingly rich source of Adipose Derived Cells which is very easy to harvest. ADC from your own fat speeds up the production of new cells and stimulates your tissue ability to repair itself. Damaged tissue cells causing lines , wrinkles and superficial imperfections are quickly outnumbered by the proliferation of healthy cells.

HOW DOES IT WORK?
Adipose Derived Cells contained in LIPOSKILL naturally restores lost volume by filling the wrinkles and feeds the skin enriching collagen and elastin which refurbishes the extra-cellular matrix. This natural product carries out filling using only autologous biological material and also stimulates cell regeneration due to cytokines and growth factors that are secreted by cells themselves. As proved by numerous scientific studies, ADC’s can produce vascularised and organised adipose tissue which doesn’t change its cellular structure and metabolic activity.

RESULTS
HOW DO THE RESULT LAST?
The conditions of application are the same as for all the fillers that are in the market with the important difference being, that the wrinkles are filled exclusively with one’s own cells and not with artificial components. The fillers that are on the market last until they are absorbed while LIPOSKILL lasts as long as the cells injected persist within the skin for a few years . Lastly it is important to mention that the effectiveness of the treatment is subject to genetic make-up, age and lifestyle.

STEP BY STEP PROCEDURE
From only one harvest of 20 mL of FAT it is possible to obtain about 10 vials of cells that can be used for many treatments. The exclusive processes of Bioscience guarantee the isolation and expansion of Adipose Derived Cells that may be used immediately to perform a treatment and can be frozen for future treatments.

INDICATIONS
∗ Glabellar Lines
∗ Lateral Brow
∗ Marionette Lines
∗ Nasolabial Fold
∗ Nose Reshaping

NATURAL BODY SHAPING – LIPOSKILL PLUS

BREAST AND BUTTOCKS AUGMENTATION WITH YOUR CELLS, WITHOUT SURGERY AND PROSTHESIS
Natural Breast and Buttocks augmentation and shaping of concave deformities without any permanent implants by a safe and quick treatment is possible. LIPOSKILL restores volume and contours body surfaces using hundreds of millions of expanded Adipose Derived Cells which are implanted using a scaffold consisting of autologous fat taken in advance.

TO AVOID SURGERY AND IMPLANTS
• Significantly reduces prolonged downtime and discomfort as well as the scarring and risks involved with all surgical procedures.
• Furthermore, eliminates many of the concerns patients have about surgery such as undergoing general anesthesia and potential scarring.
• Permanent implants typically involve major surgery under general anesthesia which can leave extensive scarring and is associated with other medical and surgical risks.

THE VOLUME ENHANCEMENT WITH AUTOLOGOUS CELLS
Unlike artificial implants, Adipose Derived Cells (ADC) in a natural fat scaffold allows more flexibility to shape and contour exactly the way you want, leading to a more personalized, natural-looking result. Many patients like the idea of using their own natural fat instead of introducing foreign materials into the body since there is a lower risk of infection or other complications. (Brayfield C, Marra K, Rubin JP. Adipose stem cells for soft tissue regeneration. Handchir Mikrochir Plast Chir. 2010).

THE PROCEDURE
The procedure consists of two phases: the first is taking the fat to extract and expand the fat cells. The second is collecting the fat to use as a scaffold that will be enriched with the expanded cells and then implanted. By a withdrawal of fat of about 50-100 ml within 10 days, approximately 300 to 600 million cells are obtained. Then, the expanded cells are combined with 100-200 ml of autologous fat and implanted to increase the volume. Thus obtaining a vascularized and organized panniculus adiposus which remains in the time.

STEP BY STEP PROCEDURE
Consists of two phases: the first is taking the FAT to extract and expand the ADCs. The second is collecting the FAT to use as a scaffold that will be enriched with the expanded cells and then implanted to increase the Volume.

ADVANTAGES OF A TREATMENT WITH LIPOSKILL
1. Get instant results with a tailor-made aesthetic treatment
2. Feel secure with a non-surgical and less invasive body shaping and body enhancement
3. Return quickly to daily activities without a post-treatment recovery period
4. Feel confident with a natural and safe material in your body
5. Cellular expansion is the only existing procedure in the world that allows the production of a significant amount of ADC for therapeutic purposes.
6. The sample can be taken via a simple micro-liposuction procedure, removing the need for surgery.

RESULTS
LIPOSKILL instantly restores volume to the breast and buttocks for a natural look with a simple injection treatment. Individual results will depend on many factors, including the amount of fat available from donor sites and the increase in volume desired. The increase in volume that you get depends on the amount of fat that is used for the scaffold. (Stig-Frederik Enrichment of autologous fat grafts with ex-vivo expanded adipose tissue-derived stem cells for graft survival: a randomised placebo-controlled trial Lancet 2013).

HOW LONG DO THE RESULTS LAST ?
The study done in vivo on humans, published on The Lancet 2013 has demonstrated that volume enhancement performed only with FAT (without expanded ADCs enrichment) is reduced by 86% in just four months. The same study demonstrates that the use of expanded ADCs limits the reduction of only 19% over the same period of time. Bioscience Institute Research & Development performed the same protocol as The Lancet study on their patients treated for breast augmentation and has demonstrated that after four months the volume reduction is only 10% (sometimes the residual volume was 100%).

NATURAL RESULTS AND NO OIL CYSTS

The soft tissue augmentation with ADCs treatment feels more natural and similar to existing tissue. It was found that the tissue had the same kind of softness as the natural tissue, which makes it far more appealing. For breast augmentation the treatment expects to enhance the attractiveness of the breast by increasing the volume and texture of the tissues rather than lift it.

INDICATIONS
∗ Breast Augmentation
∗ Buttock Augmentation
∗ Penis Enlargement
∗ Cheek Augmentation
∗ Chin Augmentation
∗ Lips Enhancement

The Bioscience Institute laboratories carry out extraction, isolation, characterization, expansion and cryopreservation of (Adipose Derived Stem Cells) following standard operational procedures (SOP). s are isolated starting from a fat tissue sample (about 10ml) which can be collected during a surgical liposuction or in one outpatient session.

The sample is transported to the Bioscience Institute laboratories in a special container.

The first part of the processing consists of the s from this sample, through enzymatic digestion.

The isolated cells are injected in flasks for cell culture and incubated at 37°C. The culture can be continued until the required number of cells is obtained and anyway not beyond the 4th stage of expansion.

The cells can be frozen at any stage in culture, but no more than twice, LIPOSKILL in fact foresees two protocols:
- Cryopreservation of stem cells extracted from the fat sample and potential grafts
- Immediate graft and potential cryopreservation

In this way it is possible to use the isolated fat stem cells for repeated treatments over the years according to patient needs.

Adipose Derived Stem Cells

Adipose Derived Stem Cells are mesenchymal stem cells found in the fat tissue; they constitute a multipotent cellular population which can differentiate into cells of various tissues, including bone, cartilage, heart and muscle.
Moreover, those cells have immunomodulating properties and an elevated capacity to retrieve and secrete angiogenic stimulating factors through endothelial cell retrieval and proliferation.
Adipose derived stem cells are also contained in the bone marrow, in the amniotic liquid and epithelial tissue.

Mesenchymal stem cells sampled from fat tissue () present the superficial markers typical of stem cells of mesenchymal nature. Such markers can be analyzed through flow cytofluorimetry, a technique which allows the measuring of individual physical and/or chemical characteristics of cells in suspension.

The main cellular lines into which the differentiate are:

Adipogenesis
Osteogenesis
Chondrogenesis
Myogenesis
Haematopoietic and vascular uses

Some of the treated pathologies:

Osteoarthritis
Autoimmune encephalomyelitis (EAE)
Refractory Chronic Autoimmune Thrombocytopenic Purpura
Complex perianal fistula
Rheumatoid arthritis

• Using your own cells prevents any risk of contagion so LIPOSKILL guarantees SAFE and NATURAL results

• Treatments are made with cells that are younger in age than the patient because the cryopreservation pauses the aging cells.

• No need to repeat collection of fat as the treatment may be repeated several times woth banked cells

• Quick return to daily activities without post-tretatment recovery period

Date Journal Headline Authors Link
2014 Jul Am Heart J. Adipose-derived regenerative cells in patients with ischemic cardiomyopathy: The PRECISE Trial. Perin EC1, Sanz-Ruiz R2, Sánchez PL2, Lasso J3, Pérez-Cano R3, Alonso-Farto JC4, Pérez-David E2, Fernández-Santos ME5, Serruys PW6, Duckers HJ6, Kastrup J7, Chamuleau S8, Zheng Y1, Silva GV1, Willerson JT1, Fernández-Avilés F9.
2014 Apr Stem Cells Transl Med Adipose stem cells used to reconstruct 13 cases with cranio-maxillofacial hard-tissue defects. Sándor GK1, Numminen J, Wolff J, Thesleff T, Miettinen A, Tuovinen VJ, Mannerström B, Patrikoski M, Seppänen R, Miettinen S, Rautiainen M, Öhman J.
2014 Feb Cytotherapy. Phase I trial: the use of autologous cultured adipose-derived stroma/stem cells to treat patients with non-revascularizable critical limb ischemia. Bura A1, Planat-Benard V2, Bourin P3, Silvestre JS4, Gross F5, Grolleau JL6, Saint-Lebese B7, Peyrafitte JA2, Fleury S2, Gadelorge M2, Taurand M2, Dupuis-Coronas S2, Leobon B8, Casteilla L9.
2013 Nov Stem Cells. Autologous adipose tissue-derived stem cells treatment demonstrated favorable and sustainable therapeutic effect for Crohn's fistula. Lee WY1, Park KJ, Cho YB, Yoon SN, Song KH, Kim do S, Jung SH, Kim M, Yoo HW, Kim I, Ha H, Yu CS.
2013 Sep Cytotherapy. Pooled human platelet lysate versus fetal bovine serum-investigating the proliferation rate, chromosome stability and angiogenic potential of human adipose tissue-derived stem cells intended for clinical use. Trojahn Kølle SF1, Oliveri RS, Glovinski PV, Kirchhoff M, Mathiasen AB, Elberg JJ, Andersen PS, Drzewiecki KT, Fischer-Nielsen A.
2013 Sep Lancet. Enrichment of autologous fat grafts with ex-vivo expanded adipose tissue-derived stem cells for graft survival: a randomised placebo-controlled trial. Kølle SF1, Fischer-Nielsen A, Mathiasen AB, Elberg JJ, Oliveri RS, Glovinski PV, Kastrup J, Kirchhoff M, Rasmussen BS, Talman ML, Thomsen C, Dickmeiss E, Drzewiecki KT.
2013 Jul Plast Reconstr Surg. Fat grafts supplemented with adipose-derived stromal cells in the rehabilitation of patients with craniofacial microsomia. Tanikawa DY1, Aguena M, Bueno DF, Passos-Bueno MR, Alonso N.
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